Graduate Studies Faculty

Diana Gilligan, MD/PhD

Diana Gilligan, MD/PhD
Appointed 10/01/10
Women's Health Network
4317 Weiskotten Hall
766 Irving Ave.
Syracuse, NY 13210

315 464-4353

Current Appointments

Hospital Campus

  • Downtown

Clinical Section Affiliations

  • Medicine: Hematology and Oncology
  • Upstate Cancer Center: Medical Oncology

Research Programs and Affiliations

  • Biochemistry and Molecular Biology
  • Biomedical Sciences Program
  • Medicine


Education & Fellowships

  • Fellowship: Duke University Medical Center, 1994, Clinical Fellow, Hematology/Oncology
  • Fellowship: Duke University Medical Center, 1993, Postdoctoral Fellow
  • Fellowship: University of North Carolina Hospitals - Chapel Hill, 1989, Postdoctoral Fellow
  • Residency: North Carolina Memorial Hospital, 1989, Internal Medicine
  • MD/PhD: Albert Einstein College of Medicine, 1985, Anatomy and Structural Biology
  • BA: Radcliffe College, Harvard University, 1976, Biology

Research Interests

  • My research includes studies of the red blood cell membrane skeleton in patients with inherited hemolytic anemia

Specialties & Certification

  • Internal Medicine
  • Hematology
  • Medical Oncology

Diseases & Conditions Treated

  • Adult Leukemia
  • Adult Lymphoma
  • Anemia
  • Bleeding Disorders
  • Blood Clots
  • Chronic Lymphocytic Leukemia
  • Hodgkin's Lymphoma
  • Multiple Myeloma


  • Adults


  • Apheresis
  • Blood Transfusion
  • Bone Marrow Aspiration
  • Bone Marrow Biopsy
  • Bone Marrow Transplantation (BMT)
  • Chemotherapy
  • Infusional Therapies
  • Lumbar Puncture
  • Paracentesis
  • Stem Cell Collection Procedures
  • Stem Cell Transplantation
  • Thoracentesis


  • American College of Physicians (ACP), Fellow
  • American Society of Hematology (ASH)
  • American Society for Cell Biology (ASCB)

Current Hospital Privileges

  • Upstate University Hospital
  • Crouse Hospital


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My research includes studies of the red blood cell membrane skeleton in patients with inherited hemolytic anemia.  We are using techniques of comparative proteomics to identify new defects in red blood cell proteins that lead to spherocytosis.  We also use mouse models with targeted deletion of red blood cell proteins in order to understand the molecular basis for membrane fragility.  We have focused on the family of adducin proteins and we have demonstrated with knockout mice that adducin has a role in red blood cell stability, learning and memory formation, and hydrocephaly.  By comparative proteomics, we having recently demonstrated that red blood cells from beta-adducin deficient mice are also deficient in NHE1, the sodium-hydrogen exchanger.  This represents a breakthrough in understanding the molecular basis for the widespread functions of adducin.  Current studies are addressing the interaction between adducin and NHE1, in order to determine how knockout of adducin can lead to loss of NHE1 in red blood cells.

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